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Researchers Commences Two Important Tests On New HIV Vaccines In Africa

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Two new important research projects on HIV commenced in southern Africa on Thursday – a new HIV vaccine and a long-acting injectable drug.

The start of the three-year vaccine trial involving 2,600 women in southern Africa means that for the first time in more than a decade there are now two big HIV vaccine clinical trials taking place at the same time.

The new study is testing a two-vaccine combination developed by Johnson and Johnson (J&J) with the U.S. National Institutes of Health (NIH) and the Bill and Melinda Gates Foundation.

The first vaccine, also backed by NIH, began a trial last November.

Also, GlaxoSmithKline’s majority-owned ViiV Healthcare unit is starting another study enrolling 3,200 women in sub-Saharan Africa to evaluate the benefit of giving injections every two months of its experimental drug cabotegravir.

The ViiV initiative, which will run until May 2022, is funded by the NIH and the Gates Foundation. ViiV is also running another large study with its long-acting injection in HIV-uninfected men and transgender women who have sex with men. That study started in December 2016.

The latest vaccine experiments aim to build on the modest success of a trial in Thailand in 2009 when an earlier vaccine showed a 31 percent reduction in infections. “We’re making progress,” said J&J Chief Scientific Officer Paul Stoffels, who believes it should be possible to achieve effectiveness above 50 percent.

“That is the goal. Hopefully, we get much higher,” he told Reuters. The new vaccines require one dose to prime the immune system and a second shot to boost the body’s response.

The latest J&J vaccine uses so-called mosaic technology to combine immune-stimulating proteins from different HIV strains, representing different types of virus from around the world, which should produce a “global” vaccine.

One reason why making an HIV vaccine has proved so difficult in the past is the variability of the virus. Initial clinical results reported at an AIDS conference in Paris in July showed the mosaic vaccine was safe and elicited a good immune response in healthy volunteers.

Some 37 million individuals around the world currently have HIV and around 1.8 million became newly infected in 2016.

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Akin Akingbala is an international journalist based in Lagos, Nigeria. Aside being happily married, he has interests in music, sports and loves traveling.

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